Cucurbit[6]uril is an ultrasensitive (129)Xe NMR contrast agent.
نویسندگان
چکیده
A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized (129)Xe NMR methods. Here, we report that commercially available cucurbit[6]uril (CB[6]) undergoes rapid xenon exchange kinetics at 300 K, and is detectable by Hyper-CEST NMR at 1.8 pM in PBS and at 1 μM in human plasma where many molecules, including polyamines, can compete with xenon for CB[6] binding.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 43 شماره
صفحات -
تاریخ انتشار 2015